Research activities in the area of chemical biology have centered around: radical mediated DNA cleaving agents of medicinal importance, enediynes in particular; diradical generating reactions and their applications in synthesis; design of anti-TB drugs against new FAS targets; mapping of functional domains in proteins including their capture and more recently, development of matrix-free LDI MS technique for detection of small molecules and metal ions of biological importance.
In the past two decades, our group has made significant and original contribution in the area of enediynes (Chem. Comm. 2003, 2006, 2008, 2011, J. Org. Chem. 2004, Chem. Rev. 2003, 2007, Angew Chem. 2005, Angew. Chem. 2011). This is the first research group to demonstrate the use of a b-lactam ring as a molecular lock in preventing bis-propargyl sulphones from undergoing isomerization to the reactive allenic species. Subsequently, the group has shown that enediynes could be prevented from undergoing Bergman cyclization by fusion with a b-lactam ring (Chem. Commun. 1996).
Mention may be made on our work on molecules capable of generating diradicals via Myers-Saito, Garratt-Braverman and Hopf cyclization, especially the interesting work on relative reactivity towards of bis-propargyl systems towards various pathways (J. Amer. Chem. Soc, 2009; Org. Lett. 2011, Chem. Asian J. 2012, J. Org. Chem. 2016, Tetrahedron 2013, 2014).
The synthetic potential of the 2 C-C bond forming Garratt-Braverman reaction and other diradical generating reactions has been exploited to create a series of natural and unnatural skeletons of considerable biological and material's interest (J. Org. Chem 2016, 2014a, 2014b, Synlett. 2013).
Bina Kumari Singh
Area of Research: Inhibitor design, synthesis and evaluation
Area of Research: Synthetic organic and metal complex chemistry
Area of Research: Immunology