Research activities in the area of chemical biology have centered around: radical mediated DNA cleaving agents of medicinal importance, enediynes in particular; diradical generating reactions and their applications in synthesis; design of anti-TB drugs against new FAS targets; mapping of functional domains in proteins including their capture and more recently, development of matrix-free LDI MS technique for detection of small molecules and metal ions of biological importance.
In the past two decades, our group has made significant and original contribution in the area of enediynes (Chem. Comm. 2003, 2006, 2008, 2011, J. Org. Chem. 2004, Chem. Rev. 2003, 2007, Angew Chem. 2005, Angew. Chem. 2011). This is the first research group to demonstrate the use of a b-lactam ring as a molecular lock in preventing bis-propargyl sulphones from undergoing isomerization to the reactive allenic species. Subsequently, the group has shown that enediynes could be prevented from undergoing Bergman cyclization by fusion with a b-lactam ring (Chem. Commun. 1996).
Identifying the Potential New Role of RNA-Binding Motif 3 Protein (RBM3) on Cytoskeleton & cancer progression Department of Science and Technology(DST)
J C Bose Fellowship Department of Science and Technology(DST)
Bina Kumari Singh
Area of Research: Inhibitor design, synthesis and evaluation
Area of Research: synthetic and computational chemistry
Area of Research: Synthetic organic and metal complex chemistry
Area of Research: Immunology